TR Pro+ Post Procedure Aesthetic Gel

A hydrogel that helps damaged skin by creating an environment that supports the healing process. TR Pro+ hydrates skin internally whilst providing a barrier to reduce epidermal water loss.  TR Pro+ is able to cool and soothe skin and is effective in reducing the irritation and redness that often follows cosmetic procedures.

Active Ingredients

• β-glucan (Glucoprime®) – a naturally derived sugar that deeply hydrates your skin and prevents moisture loss

• Triethanolamine – balances the pH of the gel to avoid irritation to your skin

• Carbomer – allows the gel to retain water to provide you with a soothing texture and leave your skin looking bright

What is Glucoprime®

The active ingredient of TR Pro+ is Glucoprime® which is a β-glucan purified from the yeast Saccharomyces cerevisiae.  β-glucans are commonly found in fungi, plants and bacteria where they are a key component of the cell wall.  β-glucans are almost totally made of sugar, with glucose being the sugar most commonly used.

There is enormous diversity in the way the millions of glucose units are locked together depending on how the molecules are joined and their spatial location relative to adjacent molecules1. Up until recently the extraction of β-glucan has been difficult and expensive due to the challenges associated with retaining the complex branched structure of the molecule.

Preserving the native structure of the β-glucan is important because it determines its ability to interact with host cells, and studies have confirmed that β-glucans which have maintained the natural branched structure are more effective in assisting damaged skin3. However, this has been difficult to achieve with investigators often reporting the breakage of linkages that lead to smaller molecules with reduced immunomodulatory effects.  Tissue Repair has successfully developed a process that leaves the native structure intact, thereby allowing Glucoprime® to exert a positive healing influence on damaged skin.

How does TR Pro+ assist with skin healing?

Film-forming, Flexible, Full Contact

TR Pro+ dries to form a thin, transparent and durable protective film that stays in constant contact with the skin.

Hydration and Water Loss

TR Pro+ is partially absorbed into the skin to provide hydration while at the same time providing a barrier to reduce epidermal water loss4,5.

Aesthetic Benefit

TR Pro+ has been shown in clinical trials to reduce skin wrinkling and increase elastosis6.

Wound Healing and Scar Formation

TR Pro+ absorbs exudate leading to improved wound healing5. Increased hydration provides an environment favourable to normal scar formation8.

Protection

TR Pro+ provides a barrier that protects against microbial infection while at the same time allowing the skin to breathe4.

Cooling Effect

TR Pro+ provides a cooling effect to soothe damaged skin and helps relieve pain and itching. Heat generated from cosmetic procedures is able to dissipate freely4.

Reduces Oxidative Stress

TR Pro+ has antioxidant capacity to protect skin against oxidative stress that may be caused by UV radiation9.

Stops Bleeding

TR Pro+ acts as a haemostatic agent to stop bleeding10.

Cosmetically Elegant

Upon being left to dry and absorb into the skin, TR Pro+ is not visible and can have makeup and sunscreen applied. 

Easy to Use and Non-reactive 

TR Pro+ can be applied once daily, is non-greasy, and can easily be removed from clothes.  TR Pro+ is neutral pH, and does not contain any preservatives, fragrances, or parabens making it suitable for people with sensitive skin.

What role does β-glucan play in skincare?

The Importance of Hydration

The water content of the stratum corneum and skin surface is not only important in the appearance of the skin, but balanced hydration is also necessary for optimal healing.

TR Pro+ is able to increase hydration in the epidermis due to the water-holding capacity of the hydrogel, while at the same time reducing trans-epidermal water loss by providing a biofilm barrier8.

Moist wound healing provides a range of benefits which includes reduced scarring, lower infection rates and faster epithelialisation8.

“The results showed that beta-glucan, despite its large molecular size, deeply penetrated the skin into the epidermis and dermis.”
Dr Ravi Pillai IFSCC Magazine Jan/Mar 2005: Vol 8, No 1.

Anti-ageing

Wrinkle formation is a sign of ageing caused by the loss of structural protein in the skin.  Pillai et al 11 tested the effects of β-glucan on facial fine lines and wrinkles in 27 patients. After twice daily use over 8 weeks, they demonstrated a reduction in all wrinkles (including deep wrinkles) as well as reductions in the average peak and roughness.

TR Pro+ also has potent antioxidant properties which combat oxidative stress brought on by the effects of sunlight and pollutants9.

 

Clinical Study

Phase IIB: Study to Evaluate a Novel Hydrogel for Optimization of Healing and Skin Quality After CO2 Laser Resurfacing of the Chest (TR987-2016-FullChest, USA, 2020)

  • Randomised, double-blind, placebo-controlled study at a single study site with 42 patients.
  • Standardised fractionated CO2 laser procedure on the full chest area to mimic a standardised wound and treated with active or placebo gel for 5 consecutive days with skin quality assessed at 28 and 104 days.
  • Validated 3- and 9-point Fitzpatrick-Goldman Wrinkle and Elastosis Scale (respectively) used to evaluate efficacy.

Clinical trial demonstrated that TR Pro+ is able to assist healing and enhance skin quality by improving skin elastosis and reducing wrinkling (114% and 70% improvements, respectively).

Using TR Pro+

Immediately following the cosmetic procedure, apply a generous layer of the gel on the affected area similar to the application of a mask. Allow some time for the gel to absorb into the skin and form a biofilm on the skin surface.

There may be a brief stinging sensation before the cooling effect of the gel starts to work. Repeat this application daily for the next 4 days.  After day 5 the gel can be applied every second day, or consistent with the advice of your healthcare professional.

The gel is best applied during the evening, but can also be applied in the morning depending on the treatment location. Do not shower within 8 hours of applying the gel.

Sunscreen and other lotions can be applied after 7 days, and once the gel has absorbed into the skin.

TR Pro+ can be used with a range of minimally invasive cosmetic procedures including:

Always read the label and use only as directed. For external use only. Keep out of reach of children. For further instructions, please refer to the Patient Information Leaflet which is available on trproplus.com

References
  1. Vetvicka, V. et al, Molecules. 2019; 24, 1251: 1-17
  2. Du, B. et al, Int J Mol Sci. 2019; 20, 4032: 1-18
  3. Goodridge, HS. et al, Nature 2011; 472(7344):471-475
  4. Harrison, IP and Spada, F. Pharmaceutics 2018; 10;71 1-13
  5. Cao, Y et al, J Cosmet Dermatol. 2021; 20:1756-176
  6. Tissue Repair – manuscript in preparation 2021
  7. Madaghiele, M. et al, Burns and Trauma. 2014; 2(4): 153-161
  8. Ousey, K. et al,  J Wound Care. 2016; (25(3): 122-130
  9. Bacha, U. et al,  2017. BioMed Res International https://doi.org/10.1155/2017/8972678
  10. Fan, F. et al, Frontiers in Bioeng and Biotech. 2021; 9:1-24
  11. Pillai, R. et al, IFSCC. 2005; 8(1): 1-6
Active Ingredients
Active Ingredients
Active Ingredients

• β-glucan (Glucoprime®) – a naturally derived sugar that deeply hydrates your skin and prevents moisture loss

• Triethanolamine – balances the pH of the gel to avoid irritation to your skin

• Carbomer – allows the gel to retain water to provide you with a soothing texture and leave your skin looking bright

Active Ingredients
What is Glucoprime®

The active ingredient of TR Pro+ is Glucoprime® which is a β-glucan purified from the yeast Saccharomyces cerevisiae.  β-glucans are commonly found in fungi, plants and bacteria where they are a key component of the cell wall.  β-glucans are almost totally made of sugar, with glucose being the sugar most commonly used.

There is enormous diversity in the way the millions of glucose units are locked together depending on how the molecules are joined and their spatial location relative to adjacent molecules1. Up until recently the extraction of β-glucan has been difficult and expensive due to the challenges associated with retaining the complex branched structure of the molecule.

Preserving the native structure of the β-glucan is important because it determines its ability to interact with host cells, and studies have confirmed that β-glucans which have maintained the natural branched structure are more effective in assisting damaged skin3. However, this has been difficult to achieve with investigators often reporting the breakage of linkages that lead to smaller molecules with reduced immunomodulatory effects.  Tissue Repair has successfully developed a process that leaves the native structure intact, thereby allowing Glucoprime® to exert a positive healing influence on damaged skin.

Active Ingredients
How does TR Pro+ assist with skin healing?

Film-forming, Flexible, Full Contact

TR Pro+ dries to form a thin, transparent and durable protective film that stays in constant contact with the skin.

Hydration and Water Loss

TR Pro+ is partially absorbed into the skin to provide hydration while at the same time providing a barrier to reduce epidermal water loss4,5.

Aesthetic Benefit

TR Pro+ has been shown in clinical trials to reduce skin wrinkling and increase elastosis6.

Wound Healing and Scar Formation

TR Pro+ absorbs exudate leading to improved wound healing5. Increased hydration provides an environment favourable to normal scar formation8.

Protection

TR Pro+ provides a barrier that protects against microbial infection while at the same time allowing the skin to breathe4.

Cooling Effect

TR Pro+ provides a cooling effect to soothe damaged skin and helps relieve pain and itching. Heat generated from cosmetic procedures is able to dissipate freely4.

Reduces Oxidative Stress

TR Pro+ has antioxidant capacity to protect skin against oxidative stress that may be caused by UV radiation9.

Stops Bleeding

TR Pro+ acts as a haemostatic agent to stop bleeding10.

Cosmetically Elegant

Upon being left to dry and absorb into the skin, TR Pro+ is not visible and can have makeup and sunscreen applied. 

Easy to Use and Non-reactive 

TR Pro+ can be applied once daily, is non-greasy, and can easily be removed from clothes.  TR Pro+ is neutral pH, and does not contain any preservatives, fragrances, or parabens making it suitable for people with sensitive skin.

Active Ingredients
What role does β-glucan play in skincare?

The Importance of Hydration

The water content of the stratum corneum and skin surface is not only important in the appearance of the skin, but balanced hydration is also necessary for optimal healing.

TR Pro+ is able to increase hydration in the epidermis due to the water-holding capacity of the hydrogel, while at the same time reducing trans-epidermal water loss by providing a biofilm barrier8.

Moist wound healing provides a range of benefits which includes reduced scarring, lower infection rates and faster epithelialisation8.

“The results showed that beta-glucan, despite its large molecular size, deeply penetrated the skin into the epidermis and dermis.”
Dr Ravi Pillai IFSCC Magazine Jan/Mar 2005: Vol 8, No 1.

Anti-ageing

Wrinkle formation is a sign of ageing caused by the loss of structural protein in the skin.  Pillai et al 11 tested the effects of β-glucan on facial fine lines and wrinkles in 27 patients. After twice daily use over 8 weeks, they demonstrated a reduction in all wrinkles (including deep wrinkles) as well as reductions in the average peak and roughness.

TR Pro+ also has potent antioxidant properties which combat oxidative stress brought on by the effects of sunlight and pollutants9.

 

Active Ingredients
Clinical Study

Phase IIB: Study to Evaluate a Novel Hydrogel for Optimization of Healing and Skin Quality After CO2 Laser Resurfacing of the Chest (TR987-2016-FullChest, USA, 2020)

  • Randomised, double-blind, placebo-controlled study at a single study site with 42 patients.
  • Standardised fractionated CO2 laser procedure on the full chest area to mimic a standardised wound and treated with active or placebo gel for 5 consecutive days with skin quality assessed at 28 and 104 days.
  • Validated 3- and 9-point Fitzpatrick-Goldman Wrinkle and Elastosis Scale (respectively) used to evaluate efficacy.

Clinical trial demonstrated that TR Pro+ is able to assist healing and enhance skin quality by improving skin elastosis and reducing wrinkling (114% and 70% improvements, respectively).

Active Ingredients
Using TR Pro+

Immediately following the cosmetic procedure, apply a generous layer of the gel on the affected area similar to the application of a mask. Allow some time for the gel to absorb into the skin and form a biofilm on the skin surface.

There may be a brief stinging sensation before the cooling effect of the gel starts to work. Repeat this application daily for the next 4 days.  After day 5 the gel can be applied every second day, or consistent with the advice of your healthcare professional.

The gel is best applied during the evening, but can also be applied in the morning depending on the treatment location. Do not shower within 8 hours of applying the gel.

Sunscreen and other lotions can be applied after 7 days, and once the gel has absorbed into the skin.

TR Pro+ can be used with a range of minimally invasive cosmetic procedures including:

Always read the label and use only as directed. For external use only. Keep out of reach of children. For further instructions, please refer to the Patient Information Leaflet which is available on trproplus.com

Active Ingredients
References
  1. Vetvicka, V. et al, Molecules. 2019; 24, 1251: 1-17
  2. Du, B. et al, Int J Mol Sci. 2019; 20, 4032: 1-18
  3. Goodridge, HS. et al, Nature 2011; 472(7344):471-475
  4. Harrison, IP and Spada, F. Pharmaceutics 2018; 10;71 1-13
  5. Cao, Y et al, J Cosmet Dermatol. 2021; 20:1756-176
  6. Tissue Repair – manuscript in preparation 2021
  7. Madaghiele, M. et al, Burns and Trauma. 2014; 2(4): 153-161
  8. Ousey, K. et al,  J Wound Care. 2016; (25(3): 122-130
  9. Bacha, U. et al,  2017. BioMed Res International https://doi.org/10.1155/2017/8972678
  10. Fan, F. et al, Frontiers in Bioeng and Biotech. 2021; 9:1-24
  11. Pillai, R. et al, IFSCC. 2005; 8(1): 1-6
Active Ingredients