TR Pro+™

A hydrogel that helps damaged skin by creating an environment that supports the healing process. TR Pro+™ hydrates skin internally whilst providing a barrier to reduce epidermal water loss.  TR Pro+™ is able to cool and soothe skin and is effective in reducing the irritation and redness that often follows cosmetic and other minor surgical procedures.

Active Ingredients

• β-glucan (Glucoprime®) – a naturally derived sugar that deeply hydrates your skin and prevents moisture loss

• Triethanolamine – balances the pH of the gel to avoid irritation to your skin

• Carbomer – allows the gel to retain water to provide you with a soothing texture and leave your skin looking bright

• Neutral pH, no parabens or fragrances means TR Pro+™ is suitable for sensitive skin

What is Glucoprime®

The active ingredient of TR Pro+™ is Glucoprime® which is a β-glucan purified from the yeast Saccharomyces cerevisiae.  β-glucans are commonly found in fungi, plants and bacteria where they are a key component of the cell wall.  β-glucans are almost totally made of sugar, with glucose being the sugar most commonly used.

There is enormous diversity in the way the millions of glucose units are locked together depending on how the molecules are joined and their spatial location relative to adjacent molecules (Vetvicka et al, 2019). Up until recently the extraction of β-glucan has been difficult and expensive due to the challenges associated with retaining the complex branched structure of the molecule.

Preserving the native structure of the β-glucan is essential because it determines its ability to interact with host cells, and studies have confirmed that β-glucans which have maintained the natural branched structure are more effective in assisting damaged skin³. Historically however, this has been difficult to achieve with most β-glucans ending up smaller after purification and therefore having reduced effects.  Tissue Repair has successfully developed a process that leaves the native structure intact, thereby allowing Glucoprime® to exert a positive healing influence on damaged skin.

How does TR Pro+™ assist with skin healing?

Film-forming, Flexible, Full Contact

TR Pro+™ dries to form a thin, transparent and durable protective film that stays in constant contact with the skin.

Hydration and Water Loss

TR Pro+™ is partially absorbed into the skin to provide hydration while at the same time providing a barrier to reduce epidermal water loss4,5.

Aesthetic Benefit

TR Pro+™ has been shown in clinical trials to reduce skin wrinkling and increase elastosis6.

Wound Healing and Scar Formation

TR Pro+™ absorbs exudate leading to improved wound healing5. Increased hydration provides an environment favourable to normal scar formation8.

Protection

TR Pro+™ provides a barrier that protects against microbial infection while at the same time allowing the skin to breathe4.

Cooling Effect

TR Pro+™ provides a cooling effect to soothe damaged skin and helps relieve pain and itching. Heat generated from cosmetic procedures is able to dissipate freely4.

Reduces Oxidative Stress

TR Pro+™ has antioxidant capacity to protect skin against oxidative stress that may be caused by UV radiation9.

Stops Bleeding

TR Pro+™ acts as a haemostatic agent to stop bleeding10.

Cosmetically Elegant

Upon being left to dry and absorb into the skin, TR Pro+™ is not visible and can have makeup and sunscreen applied. 

Easy to Use and Non-reactive 

TR Pro+™ can be applied once daily, is non-greasy, and can easily be removed from clothes.  TR Pro+™ is neutral pH, and does not contain any preservatives, fragrances, or parabens making it suitable for people with sensitive skin.

What role does β-glucan play in skincare?

Moisturise

The water content of the stratum corneum and skin surface is important in the appearance and function of skin (Cheng et al, 2007).  Moisturisers reduce the loss of skin humidity and increase hydration to make it moist, smooth and soft  (Kim et al, 2018).  For a long time it was believed that the large molecular structure of β-glucans would prevent it from effectively penetrating the skin. This all changed following a clinical study (Pillai et al, 2005) which evaluated the effects of β-glucan in the reduction of wrinkle depth and height. The researchers applied β-glucan to skin samples and left it to absorb for 8 hours before examining the samples and finding that it was able to enter the stratum corneum and epidermis and penetrate into the dermis.  It’s also interesting to note that β-glucan does not penetrate the skin by moving through individual cells, but instead passes in the spaces between cells.

Hyaluronic acid is well known for its moisturising effects on the skin.  However hyaluronic acid is water-retaining and not water-generating as is the case with β-glucan.  Where hyaluronic acid cannot penetrate the skin unless it’s injected, β-glucan  can readily penetrate to the dermis and has been reported to have 20% greater hydrating ability than hyaluronic acid at the same concentration (https://www.kosmeticimmunity.com/blogs/rhos/bgvsha).

“The results showed that beta-glucan, despite its large molecular size, deeply penetrated the skin into the epidermis and dermis.”
Dr Ravi Pillai IFSCC Magazine Jan/Mar 2005: Vol 8, No 1.

Anti-ageing (by temporarily reducing the depth of wrinkles)

Wrinkle formation is one of the main signs of ageing and the major cause of fine wrinkles is the loss of structural protein, or collagen, in the dermal layer of skin.  Collagen makes up 70-80% of the dry weight of skin (Du et al 2014) and the amount of collagen varies from person to person. In a study published in the International Journal of Cosmetic Science (Pillai et al, 2005), 27 people were tested to evaluate the effects of β-glucan on facial fine lines and wrinkles.  After twice daily use over 8 weeks, they found that there was a reduction in all wrinkles (including deep wrinkles) as well reductions in the average peak and roughness.

β-glucans have also been shown to have potent antioxidant properties.  Given that oxidative stress from free radicals is a major cause of skin ageing, these antioxidant properties are beneficial to combat the ageing effects of sunlight and pollutants.

Reduce skin irritation and redness

The β-glucan (Glucoprime®) in TR Pro+™ protects the skin from external stressors and irritation by increasing your skin’s natural barrier and preventing harmful bacteria or pollution from making their way into your skin. It aids in providing relief from excessive sun exposure, rashes and mild burns.  Glucoprime® provides a film-forming linear polymer, which means that it links together to form a thin, undetectable barrier that enhances the natural protecting properties of the skin layer.   Its ability to penetrate deep into the skin serves to immediately calm down redness and irritation caused after cosmetic treatments.

TR Pro+™ is specifically designed to support the skin’s natural barrier function and works to diminish the appearance of redness. Gentle enough for dry and sensitive skin types, use it once daily or as needed, massaging a small amount onto the affected areas.

TR Pro+™ containing β-glucan, is suitable for all skin types. It’s fragrance-free and colour free which makes it a firm favourite with both women and men. This oil-free gel works to instantly boost skin’s hydration, giving you a healthy supple complexion.

Clinical Study

Phase 2B Study: Wu D, Kollipara R, Carter M, and Goldman M. A Novel Macrophage- Activating Gel Improves Healing and Skin Quality After CO2 Laser Resurfacing of the Chest. Dermatologic Surgery 2022; December 2022 48(12): 1312-1316

  • Randomised, double-blind, placebo-controlled study at a single study site with 42 patients.
  • Standardised fractionated CO2 laser procedure on the full chest area to mimic a standardised wound and treated with active or placebo gel for 5 consecutive days with skin quality assessed at 28 and 104 days.
  • Validated 3- and 9-point Fitzpatrick-Goldman Wrinkle and Elastosis Scale (respectively) used to evaluate efficacy.

Clinical trial demonstrated that TR Pro+™ is able to assist healing and enhance skin quality by improving skin elastosis and reducing wrinkling (114% and 70% improvements, respectively).

Link to access and download the publication

Real-World Evidence Study

Twelve dermatology clinics enrolled patients between April and September 2022 and administered TR Pro+TM following a range of procedures.  The instructions specified use for at least 5 days. Patients provided feedback via an anonymous online portal at days 6 and 28.  There were 48 patients who completed both surveys.  The study was run independently by IQVIA Solutions Australia Pty Ltd.

Use the following link to download the complete publication TR Pro+ – Real World Evidence Study 2022.

Using TR Pro+™

TR Pro+™ can be used with a range of minimally invasive cosmetic procedures including:

  • Laser skin resurfacing
  • Needling
  • Cosmetic light procedures (IPL, BBL, LED)
  • Chemical peels
  • Dermabrasion
  • Biopsy
  • Skin cancer removal
  • Electrolysis
  • Tattoo removal
  • Minor incisions

Detailed instructions for use are provided in the TR Pro+ Product Brochure.

In general, TR Pro+™ can be applied directly after the procedure, and from then on in the evening and then left to absorb into the skin overnight.  A loose dressing can be used to cover the area if necessary. The skin is gently cleansed the following morning, and if appropriate, moisturiser can be applied throughout the day to ensure the skin surface does not become dry.  TR Pro+™ is applied in the same way each evening for 5 days, and then every second evening afterwards as required or until the skin returns to normal.

There may be a brief mild stinging sensation before the cooling effect of the gel becomes apparent, at which time there may also be a feeling of skin tightening which is normal.

References
  1. Cheng Y, Dong Y, Dong M, Wang C, Sun Y, Su N, Liu J, Zheng H, Yang X, Li J, Andreas S, Rohr M, Liu W. Moisturizing and antisebum effect of cosmetic application on facial skin. J Cosmet Dermatol. 2007 Sep;6(3):172-7.
  2. Du B, Bian Z, Xu B. Skin health promotion effects of natural beta-glucan derived from cereals and microorganisms: a review. Phytother Res. 2014 Feb;28(2):159-66.
  3. Kim H, Kim JT, Barua S, Yoo SY, Hong SC, Lee KB, Lee J. Seeking better topical delivery technologies of moisturizing agents for enhanced skin moisturization. Expert Opin Drug Deliv. 2018 Jan;15(1):17-31.
  4. Pillai R, Redmond M, Roding J. Anti‐Wrinkle Therapy: Significant New Findings in the Non‐Invasive Cosmetic Treatment of Skin Wrinkles with Beta‐Glucan. International Journal of Cosmetic Science 2005 8: 2-6.
  5. Vetvicka V, Vannucci L, Sima P, Richter J. Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials. Molecules. 2019 Mar 30;24(7):1251
  6. Wu, D, et al, Dermatologic Surgery 2022; December 2022 48(12): 1312-1316
Active Ingredients
Active Ingredients
Active Ingredients

• β-glucan (Glucoprime®) – a naturally derived sugar that deeply hydrates your skin and prevents moisture loss

• Triethanolamine – balances the pH of the gel to avoid irritation to your skin

• Carbomer – allows the gel to retain water to provide you with a soothing texture and leave your skin looking bright

• Neutral pH, no parabens or fragrances means TR Pro+™ is suitable for sensitive skin

Active Ingredients
What is Glucoprime®

The active ingredient of TR Pro+™ is Glucoprime® which is a β-glucan purified from the yeast Saccharomyces cerevisiae.  β-glucans are commonly found in fungi, plants and bacteria where they are a key component of the cell wall.  β-glucans are almost totally made of sugar, with glucose being the sugar most commonly used.

There is enormous diversity in the way the millions of glucose units are locked together depending on how the molecules are joined and their spatial location relative to adjacent molecules (Vetvicka et al, 2019). Up until recently the extraction of β-glucan has been difficult and expensive due to the challenges associated with retaining the complex branched structure of the molecule.

Preserving the native structure of the β-glucan is essential because it determines its ability to interact with host cells, and studies have confirmed that β-glucans which have maintained the natural branched structure are more effective in assisting damaged skin³. Historically however, this has been difficult to achieve with most β-glucans ending up smaller after purification and therefore having reduced effects.  Tissue Repair has successfully developed a process that leaves the native structure intact, thereby allowing Glucoprime® to exert a positive healing influence on damaged skin.

Active Ingredients
How does TR Pro+™ assist with skin healing?

Film-forming, Flexible, Full Contact

TR Pro+™ dries to form a thin, transparent and durable protective film that stays in constant contact with the skin.

Hydration and Water Loss

TR Pro+™ is partially absorbed into the skin to provide hydration while at the same time providing a barrier to reduce epidermal water loss4,5.

Aesthetic Benefit

TR Pro+™ has been shown in clinical trials to reduce skin wrinkling and increase elastosis6.

Wound Healing and Scar Formation

TR Pro+™ absorbs exudate leading to improved wound healing5. Increased hydration provides an environment favourable to normal scar formation8.

Protection

TR Pro+™ provides a barrier that protects against microbial infection while at the same time allowing the skin to breathe4.

Cooling Effect

TR Pro+™ provides a cooling effect to soothe damaged skin and helps relieve pain and itching. Heat generated from cosmetic procedures is able to dissipate freely4.

Reduces Oxidative Stress

TR Pro+™ has antioxidant capacity to protect skin against oxidative stress that may be caused by UV radiation9.

Stops Bleeding

TR Pro+™ acts as a haemostatic agent to stop bleeding10.

Cosmetically Elegant

Upon being left to dry and absorb into the skin, TR Pro+™ is not visible and can have makeup and sunscreen applied. 

Easy to Use and Non-reactive 

TR Pro+™ can be applied once daily, is non-greasy, and can easily be removed from clothes.  TR Pro+™ is neutral pH, and does not contain any preservatives, fragrances, or parabens making it suitable for people with sensitive skin.

Active Ingredients
What role does β-glucan play in skincare?

Moisturise

The water content of the stratum corneum and skin surface is important in the appearance and function of skin (Cheng et al, 2007).  Moisturisers reduce the loss of skin humidity and increase hydration to make it moist, smooth and soft  (Kim et al, 2018).  For a long time it was believed that the large molecular structure of β-glucans would prevent it from effectively penetrating the skin. This all changed following a clinical study (Pillai et al, 2005) which evaluated the effects of β-glucan in the reduction of wrinkle depth and height. The researchers applied β-glucan to skin samples and left it to absorb for 8 hours before examining the samples and finding that it was able to enter the stratum corneum and epidermis and penetrate into the dermis.  It’s also interesting to note that β-glucan does not penetrate the skin by moving through individual cells, but instead passes in the spaces between cells.

Hyaluronic acid is well known for its moisturising effects on the skin.  However hyaluronic acid is water-retaining and not water-generating as is the case with β-glucan.  Where hyaluronic acid cannot penetrate the skin unless it’s injected, β-glucan  can readily penetrate to the dermis and has been reported to have 20% greater hydrating ability than hyaluronic acid at the same concentration (https://www.kosmeticimmunity.com/blogs/rhos/bgvsha).

“The results showed that beta-glucan, despite its large molecular size, deeply penetrated the skin into the epidermis and dermis.”
Dr Ravi Pillai IFSCC Magazine Jan/Mar 2005: Vol 8, No 1.

Anti-ageing (by temporarily reducing the depth of wrinkles)

Wrinkle formation is one of the main signs of ageing and the major cause of fine wrinkles is the loss of structural protein, or collagen, in the dermal layer of skin.  Collagen makes up 70-80% of the dry weight of skin (Du et al 2014) and the amount of collagen varies from person to person. In a study published in the International Journal of Cosmetic Science (Pillai et al, 2005), 27 people were tested to evaluate the effects of β-glucan on facial fine lines and wrinkles.  After twice daily use over 8 weeks, they found that there was a reduction in all wrinkles (including deep wrinkles) as well reductions in the average peak and roughness.

β-glucans have also been shown to have potent antioxidant properties.  Given that oxidative stress from free radicals is a major cause of skin ageing, these antioxidant properties are beneficial to combat the ageing effects of sunlight and pollutants.

Reduce skin irritation and redness

The β-glucan (Glucoprime®) in TR Pro+™ protects the skin from external stressors and irritation by increasing your skin’s natural barrier and preventing harmful bacteria or pollution from making their way into your skin. It aids in providing relief from excessive sun exposure, rashes and mild burns.  Glucoprime® provides a film-forming linear polymer, which means that it links together to form a thin, undetectable barrier that enhances the natural protecting properties of the skin layer.   Its ability to penetrate deep into the skin serves to immediately calm down redness and irritation caused after cosmetic treatments.

TR Pro+™ is specifically designed to support the skin’s natural barrier function and works to diminish the appearance of redness. Gentle enough for dry and sensitive skin types, use it once daily or as needed, massaging a small amount onto the affected areas.

TR Pro+™ containing β-glucan, is suitable for all skin types. It’s fragrance-free and colour free which makes it a firm favourite with both women and men. This oil-free gel works to instantly boost skin’s hydration, giving you a healthy supple complexion.

Active Ingredients
Clinical Study

Phase 2B Study: Wu D, Kollipara R, Carter M, and Goldman M. A Novel Macrophage- Activating Gel Improves Healing and Skin Quality After CO2 Laser Resurfacing of the Chest. Dermatologic Surgery 2022; December 2022 48(12): 1312-1316

  • Randomised, double-blind, placebo-controlled study at a single study site with 42 patients.
  • Standardised fractionated CO2 laser procedure on the full chest area to mimic a standardised wound and treated with active or placebo gel for 5 consecutive days with skin quality assessed at 28 and 104 days.
  • Validated 3- and 9-point Fitzpatrick-Goldman Wrinkle and Elastosis Scale (respectively) used to evaluate efficacy.

Clinical trial demonstrated that TR Pro+™ is able to assist healing and enhance skin quality by improving skin elastosis and reducing wrinkling (114% and 70% improvements, respectively).

Link to access and download the publication

Active Ingredients
Real-World Evidence Study

Twelve dermatology clinics enrolled patients between April and September 2022 and administered TR Pro+TM following a range of procedures.  The instructions specified use for at least 5 days. Patients provided feedback via an anonymous online portal at days 6 and 28.  There were 48 patients who completed both surveys.  The study was run independently by IQVIA Solutions Australia Pty Ltd.

Use the following link to download the complete publication TR Pro+ – Real World Evidence Study 2022.

Active Ingredients
Using TR Pro+™

TR Pro+™ can be used with a range of minimally invasive cosmetic procedures including:

  • Laser skin resurfacing
  • Needling
  • Cosmetic light procedures (IPL, BBL, LED)
  • Chemical peels
  • Dermabrasion
  • Biopsy
  • Skin cancer removal
  • Electrolysis
  • Tattoo removal
  • Minor incisions

Detailed instructions for use are provided in the TR Pro+ Product Brochure.

In general, TR Pro+™ can be applied directly after the procedure, and from then on in the evening and then left to absorb into the skin overnight.  A loose dressing can be used to cover the area if necessary. The skin is gently cleansed the following morning, and if appropriate, moisturiser can be applied throughout the day to ensure the skin surface does not become dry.  TR Pro+™ is applied in the same way each evening for 5 days, and then every second evening afterwards as required or until the skin returns to normal.

There may be a brief mild stinging sensation before the cooling effect of the gel becomes apparent, at which time there may also be a feeling of skin tightening which is normal.

Active Ingredients
References
  1. Cheng Y, Dong Y, Dong M, Wang C, Sun Y, Su N, Liu J, Zheng H, Yang X, Li J, Andreas S, Rohr M, Liu W. Moisturizing and antisebum effect of cosmetic application on facial skin. J Cosmet Dermatol. 2007 Sep;6(3):172-7.
  2. Du B, Bian Z, Xu B. Skin health promotion effects of natural beta-glucan derived from cereals and microorganisms: a review. Phytother Res. 2014 Feb;28(2):159-66.
  3. Kim H, Kim JT, Barua S, Yoo SY, Hong SC, Lee KB, Lee J. Seeking better topical delivery technologies of moisturizing agents for enhanced skin moisturization. Expert Opin Drug Deliv. 2018 Jan;15(1):17-31.
  4. Pillai R, Redmond M, Roding J. Anti‐Wrinkle Therapy: Significant New Findings in the Non‐Invasive Cosmetic Treatment of Skin Wrinkles with Beta‐Glucan. International Journal of Cosmetic Science 2005 8: 2-6.
  5. Vetvicka V, Vannucci L, Sima P, Richter J. Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials. Molecules. 2019 Mar 30;24(7):1251
  6. Wu, D, et al, Dermatologic Surgery 2022; December 2022 48(12): 1312-1316
Active Ingredients
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